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The rapid increase in the prevalence of obesity in the USA in the past 30 years has many health implications. Obesity is strongly associated with incidence and mortality of several common cancers including post-menopausal breast cancer, renal cell cancer, colorectal cancer, prostate cancer, and endometrial cancer. Obesity patterns in the USA vary substantially by race, particularly for women, with black women having a higher prevalence of obesity than white women. Moreover, black men and women experience higher incidence and mortality for many common cancers and cardiovascular disease.